In a retrospective cohort of 300 surgical patients who declined red-cell transfusion for religious reasons (operated 1981-1994), no deaths occurred at post-operative haemoglobin 7.1-8.0 g/dL (upper 95% CI 3.7%; 9.4% had a morbid event), but 34.4% (95% CI 18.6-53.2%) died at 4.1-5.0 g/dL; after adjustment, the odds of death rose about 2.5-fold for each g/dL fall. Later cohorts treated with modern patient blood management (2003-2012; 2008-2021) report lower overall mortality at haemoglobin of 8 g/dL or below (8.2% and 3.1%) with the same graded relationship (adjusted odds ratio 1.82 per g/dL for death; 1.48 per g/dL for death or morbidity).
Claim ID claim-blood-medical-carson-2002Concerns July 2002Independent finding
In a retrospective cohort of 300 surgical patients who declined red-cell transfusion for religious reasons (operated 1981-1994), no deaths occurred at post-operative haemoglobin 7.1-8.0 g/dL (upper 95% CI 3.7%; 9.4% had a morbid event), but 34.4% (95% CI 18.6-53.2%) died at 4.1-5.0 g/dL; after adjustment, the odds of death rose about 2.5-fold for each g/dL fall. Later cohorts treated with modern patient blood management (2003-2012; 2008-2021) report lower overall mortality at haemoglobin of 8 g/dL or below (8.2% and 3.1%) with the same graded relationship (adjusted odds ratio 1.82 per g/dL for death; 1.48 per g/dL for death or morbidity). Source: Transfusion, July 2002Source: Transfusion, 2014Source: Transfusion, 2024
July 2002 · pp.42(7):812-818 · Carson JL, Noveck H, Berlin JA, Gould SA · AABB / Wiley
“In patients with a postoperative Hb level of 4.1 to 5.0, 34.4 percent (95% CI, 18.6-53.2%) died”
300 of 2,083 patients declining RBC transfusion for religious reasons (1981-1994) had post-op Hb ≤ 8 g/dL; 0 deaths at 7.1-8.0; odds of death rose 2.5× per g/dL fall. PMID 12375651.
Provenance and verification note for Transfusion, Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion
Confidence note. Abstract opened via the Europe PMC REST API (PubMed blocked on cookies).
Provenance and verification note for Transfusion, An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion
2024 · pp.64:1198-1206 · Seeber P, Trentino KM, Murray K, Lucas M · AABB / Wiley
“Of these, five (3.1%) patients died in hospital within 30 days”
159 of 2,841 admissions (2008-2021, Gotha, Germany) with nadir Hb ≤ 8; each gram decrease associated with 1.48× composite morbidity/mortality. PMID 38716878.
Provenance and verification note for Transfusion, A further update on mortality and morbidity in patients with very low hemoglobin levels who decline blood transfusion
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